While some teams are playing for a bye in the first round of the playoffs, most are clawing to hold onto a playoff spot as others try to rip it away.
This time of year, there are no friends in fantasy leagues. That can be inconvenient for those looking to make trades, but the waiver-wire was bolstered greatly with depth this week after more injuries plagued key fantasy players during Week 11.
A blow to the head of LeSean McCoy is likely to keep him sidelined during Monday night's game in Philadelphia and a torn MCL will keep Broncos running back Willis McGahee out for over a month.
Those injuries will make Eagles' backup running back Bryce Brown and Denver's rookie Ronnie Hillman two of the most sought-after players on the wire this week, but another running back move in the NFL should intrigue fantasy owners far more.
Mike Mularkey is sticking with Jalen Parmele ahead of Rashad Jennings for this week's game against the Titans as Maurice Jones-Drew continues to rest an injured foot.
Parmele rushed for 80 yards on 24 carries while also catching three passes against the tough run defense of Houston, which is ranked No. 2 in the NFL against the run.
Parmele will see a great matchup against the No. 28 run defense of Tennessee this week, making him worth a start if you need to fill any holes this week.
Rob Gronkowski's forearm fracture will be a big blow to his owners, making tight ends on the wire more valuable this week.
Look toward guys such as Tennessee's Jared Cook or the Jets' Dustin Keller.
I like Keller's matchup this Thursday night against the Patriots, who Keller burned for 93 yards and a touchdown in Week 7 on the road in his second game back from injury.
Now that we have hit Thanksgiving, bye weeks are a thing of the past for the remainder of the NFL season, returning healthy lineups to full strength going forward.
A bit of advice I have learned the hard way most of this season: stick with your stars instead of trying to get too cute playing matchups.
At the end of the day, there is a reason you drafted these guys and have hung on to them this long, and now that bye weeks are over, you should have a pretty set lineup you are excited to roll out each week down the stretch.
Remember to set your lineups early with three big games this Thanksgiving. It is always fun to have a dog in the fight on Thanksgiving Day when everyone gathers around the television for snacks and football, and big players tend to shine in the spotlight.
We offer a few picks for survivor pool players this week. If you haven't used the Cincinnati Bengals, consider them a safe bet at home against Oakland this week.
If you have used the Bengals, this may be the safest week to pick the Indianapolis Colts, who host Buffalo this Sunday. The Colts need to stay in the playoff hunt and the Bills have hit the point in the season where they always tend to slide.
That is all for this week. You can continue sending in lineup questions to email@example.com or to my Twitter page at twitter.com/jlivi2.
John Livingston is the sports editor of The Daily Times and a member of the Fantasy Sports Writers Association.