On May 17, Biden will address the school's 33rd graduating class, which includes about 200 students.
Navajo Tech President Elmer J. Guy said he was honored that Biden accepted the school's invitation to speak.
"It's unbelievable. It's a blessing," Guy said. "We work hard to build our students and encourage them to get trained and educated to be a powerful work force for the Navajo Nation. This adds to the work we have been doing."
U.S. Secretary of Education Arne Duncan delivered the commencement address last year, said Navajo Tech spokesman Daniel Vandever.
"That one was a big surprise. He delivered an awesome commencement speech," Guy said.
Guy said he believed Biden's decision to deliver the speech came from Navajo Tech being selected by the Aspen Institute College Excellence Program as one of the top 120 community colleges in the country for two consecutive years.
"Dr. Biden really advocates for community colleges across the country," Guy said. "(She) recognizes the work of community colleges and how important it is in the educational field for preparing students for careers."
In her speech, Guy said he hopes Biden will share how important education, community colleges and higher education are for Native American communities.
"I think (her speech) will highlight the importance of tribal colleges and universities play and how we impact the economy in our poor communities," Guy said.
Joshua Kellogg can be reached at firstname.lastname@example.org; 505-564-4627. Follow him on Twitter @jkelloggdt.