The 60-count indictment was unsealed Monday following the arrests of 13 of the defendants. They all made their initial appearances in federal court in Albuquerque.
Authorities say the drug trafficking organization allegedly was headed by 33-year-old Christopher Roybal of Albuquerque.
According to the indictment, Roybal and others allegedly conspired to distribute quantities of marijuana and cocaine in New Mexico over the last 16 months.
Undercover officers purchased 3 1/2 kilograms of cocaine and about 18 pounds of high-grade marijuana that led to the arrests.
The indictment seeks forfeiture of numerous bank accounts as well as a money judgment of at least $4.1 million.
The 19 are accused of drug trafficking and money laundering.